Main Sequence

Unreasonable inventors are combining cutting-edge scientific discoveries with the world's biggest challenges to build the next generation of global companies. These are the companies we create and invest in at Main Sequence.

Our Advantage

Deep tech inventors need more. We have custom-built Main Sequence to be ready to help you solve some of the world's greatest challenges with science.
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We are hands-on and have built a services offering to support founders alongside our capital.

Our story

Main Sequence was founded by CSIRO in 2017 to address the ‘valley of death’ between research and commercialisation.
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Main Sequence’s origins within CSIRO reflect its commitment to amplifying connections between industry, research, and infrastructure to accelerate deep technology development and reinvesting economic returns from commercialisation back into science.
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CSIRO Innovation Funds 1 and 2 managed by Main Sequence, have invested in 51 companies since establishment in 2017. These companies have created over 2100 jobs by working with partners in industry, CSIRO, and 28 Australian universities.

The $240 million first CSIRO Innovation Fund, built on a cornerstone investment by government and CSIRO has completed its portfolio and invested in 27 companies since establishment in 2017.

The second $300 million CSIRO Innovation Fund commenced investing in mid-2021 and has invested in 24 companies.

During 2023, Fund 3 has raised $450 million, surpassing $1 billion in total funds under management and making its first five Fund 3 investments.