In my experience, first you have to identify the 3 pillars of your business:
Product / Service (or what ever you are creating) -websites, app, technology, services, products, & etc
Operations (the things that keep productions & marketing in places) -Human resource, financials, communications & etc)
Commercialization (the ways to get new & lasting revenue) -Sales, marketing, business development, branding, PR & etc)
The idea is, your job is to balance the 3 pillars for optimized outputs. Put in real thoughts in these 3 pillars, to avoid as much risk and uncertainties as possible. Don't risk too much, don't aim too low, find the balance yourself.
And let's not forget, the fuel to all 3 pillars is human.