PostEra is building a modern biopharma, using machine learning to accelerate medicinal chemistry, to develop cures for diseases, faster. We've raised $26M from top investors, secured a $68M NIH partnership to prevent pandemics, and established a $260M partnership with Pfizer. We also launched and help lead the world's largest open-science initiative to find a COVID antiviral; COVID Moonshot.
PostEra pioneered many of the advances in AI for Medicinal Chemistry and uses its platform to drive drug discovery projects from Target to Development Candidate. In addition to multi-year deals with partners like Pfizer and the NIH, we are now building internal drug discovery capabilities. We are seeking a scientifically curious and experienced biochemist with a versatile skill base and an interest in contributing to a fast-paced, team-oriented, drug discovery enterprise. The top candidates will have several years of experience in industry and across a diversity of biochemistry disciplines such as protein chemistry, protein expression & purification, biophysics, enzymology, and structural biology.
What you would do
- Biology Lead on multiple programs, from target validation to IND-enabling studies.
- Work closely with the Head of Biology and CSO to identify and evaluate targets and their mechanism of action/activation.
- Implement biology capabilities associated with PostEra’s targets including protein production, biophysical and enzymatic characterization.
- Manage implementation and execution of key experiments at multiple CROs, analyze and report data to internal team and help implement internal capabilities.
- Develop novel biochemical and biophysical assays and technologies needed for target ID/validation as well as to progress compounds from hit validation through hit to lead activities into lead optimization and beyond.
- Provide the mechanistic elucidation required for the optimization of potency and properties to inform deeper pharmacology relevant studies.
- Build the strategy associated with targets of interest, from market research to target product profile, define assay cascade and critical Go/No Go.
Experience and skills you should have
- PhD in biology or related discipline with >4 years industry experience in the field of Biochemistry, Enzymology, Biophysics or related field.
- Expertise in designing, interpreting, and troubleshooting experiments using several biophysics, bioanalytical, enzymology, and/or structural biology techniques (e.g. ITC, NMR, SPR, BLI/Octet, GCI, nanoDSF, MST, enzyme kinetics, SEC-HPLC, LC/MS)
- Broad experience in cell biology/pharmacology.
- Adept at navigating and influencing a multi-disciplinary matrix environment.
- Excellent interpersonal and communication skills, oral and written.
- Willing to travel up to 10% annually.
Bonus experience and skills
- Experience in virology (in vitro assays such as viral culture, neutralization and quantification assays, virus growth, tittering, and in vivo infection models) and/or reproductive endocrinology strongly preferred.
Salary: 150k - 200k
Equity: .10% - 0.20%
Visa Sponsorship: Not at this time
Hiring Manager: Marie-Laure Rives
Visit us at postera.ai
PostEra
